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Silent cerebral infarction was observed in 51.4%of the patients with presenile-onset presenile depression,and the incidence was significantly higher than in patients with juvenile-onset presenile depression(P<.01). Among the patients with senile major depression,silent cerebral infarction was observed in 65.9%of those with presenile-onset depression and in 93.7% of those with senile-onset depression.Our findings suggest that half of presenile-onset major depression and the majority of senile-onset major depression might be organic depression related to silent cerebral infarction.Because major depression occurring for the first time during or after the presenile period may be related to silent cerebral infarction,it is important to keep this possibility in mind when treating such patients. |
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